Other Publications

UK HER2 Testing Guidelines (2015)

This article provides an update of the guidelines for HER2 testing in the UK. It aimed to further improve the analytical validity and clinical utility of HER2 testing by providing guidelines of test performance parameters, and recommendations on the post-analytical interpretation of test results. The authors published these guidelines on behalf of the National Coordinating Committee for Breast Pathology

Macroscopic handling and reporting of neoadjuvant cases (2015)

This article describes the macroscopic handling and reporting of breast cancer specimens pre- and post-neoadjuvant chemotherapy treatment and reviews pathological issues and suggested some practical approaches

The role of histological grade (2010)

In this review article, the authors present an analysis of the validity of histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers.

Ki67 Assessment in Breast Cancer

1 – Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group (2011)

2 – An international study to increase concordance in Ki67 scoring

3 – St Gallen 2015 subtyping of luminal breast cancers: impact of different Ki67-based proliferation assessment methods (2016)

Assessment of tumour infiltrating lymphocytes (TILs)

The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014

B3 lesions

First International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) (2016)

Phyllodes tumours

This review article provides a consensus view on phyllodes tumours of the breast

UK DCIS review of margins: Breast conservation in ductal carcinoma in situ (DCIS): what defines optimal margins? (2016)

This review aims to address the clinical question of the minimal margin width in DCIS treated with breast conserving surgery (BCS) that is associated with the lowest recurrence rate. A range of clinical circumstances that might affect this are considered.

Sentinel Lymph Node in Breast Cancer: Review Article from a Pathologist’s Point of View (2016) (1), (2), (3)

These articles provide an update of the ASCO Clinical Practice Guideline and a brief history of TNM with a focus on N-stage and innate problems with the guidelines, and why pathologists may have difficulties in assessing lymph node metastases uniformly. It also describes the clinical significance of isolated tumor cells, micrometastasis, and macrometastasis

ASCO/CAP Guidelines for HER2 Testing in breast cancer (2018)

Latest recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer by the American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline.

ASCO/CAP Guidelines for ER and PR Testing in breast cancer (2010)

American Society of Clinical Oncology/College Of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer.

Assessment of Margins in Invasive Breast Cancer: ASCO/SSRO Guidelines
Also in lobular carcinoma

1-Margins for breast-conserving surgery with whole-breast irradiation in stage I and II invasive breast cancer: American Society of Clinical Oncology endorsement of the Society of Surgical Oncology/American Society for Radiation Oncology consensus guideline (2014).
2-Surgical Options and Locoregional Recurrence in Patients Diagnosed with Invasive Lobular Carcinoma of the Breast (2015)

Assessment of Margins in DCIS: ASCO/SSRO Guidelines

Society of Surgical Oncology-American Society for Radiation Oncology-American Society of Clinical Oncology Consensus Guideline on Margins for Breast Conserving Surgery With Whole Breast Irradiation in Ductal Carcinoma In Situ (2016)

Integration of NGS in clinical diagnostic laboratories (2017)

Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL

Papillary Lesions

1 – Papillary Lesions of the Breast: An Update (2016)
2 – Pathological criteria and practical issues in papillary lesions of the breast – a review (2016)
3 – Papillary lesions of the breast: selected diagnostic and management issues (2008)

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